(informal)completely
(非正式)完全地，彻底地
(informal, chiefly Brit.)when everything is taken into consideration
(非正式，主英)最终，到头来
at the end of the day I'm responsible for what happens in the school.
到头来，还是我对学校发生的事负责。
be finished or completed
结束；完毕；完成
(of a supply of something) become exhausted
（供应物）耗尽，用光
our patience has come to an end.
我们一点儿耐心都没有了。
be close to having no more of (something)
到了…的尽头，几至耗尽
she was at the end of her patience.
她简直忍无可忍。
(informal)be the limit of what one can tolerate
(非正式)是所能忍受的最大限度，达到了忍耐极限
you really are the end!.
你真让人忍无可忍！。
be led by one's own actions to ruin or an unpleasant death
遭到报应；落得悲惨下场；不得好死
a thing that is final or definitive
终结；最终结果
spend the final part of one's existence in a specified place or state
度过余生（或暮年）
she ended her days in London.
她在伦敦度过余生。
a goal that is pursued in its own right to the exclusion of others
目标本身
have an unhappy or painful outcome (often as a warning)
（常作告诫语）会有不愉快（或痛苦）的结局；有苦果
this treaty will end in tears.
这个协议会带来苦果。
commit suicide
自杀
the point beyond which progress or survival cannot continue
生命（或事物发展）的尽头；穷途末路；完蛋
if the damages award is not lowered it could be the end of the road for the publisher.
若不降低损害赔偿金，那家出版公司可能就完了。
having no patience or energy left to cope with something
忍无可忍；精疲力竭
these individuals have reached the end of their tether. .
这些人已忍无可忍（或筋疲力尽）了。
the termination of life on the earth
世界末日，世界之毁灭